For SPN? (If you meant another show, just let me know :) ) The only pairing I really dislike is Sam/Ruby. It makes me :( and >:( so I stay far away from it. Even if it is secondary in a wincest fic (my fave kind of SPN fic *g*), I won't read that fic. I'm also not a fan of John/Sam or anything with Bela.